Not much has been released about Spider-man: Web of Shadows. I hope the game has a similar engine to the movie games, and veers away from the Spider-man: Friend or Foe format. The premise, as I understand it so far:

Something very evil and massive attacks New York. As usual, our favorite web head is stuck in the middle of it. This time you get to choose who you trust, and who you leave behind. Depending on how you play the game, and who you befriend alters the ending of the game.